Journal article
Evidence of a genetic link between endometriosis and ovarian cancer
AW Lee, C Templeman, DA Stram, J Beesley, J Tyrer, A Berchuck, PP Pharoah, G Chenevix-Trench, CL Pearce, RB Ness, A Dansonka-Mieszkowska, A Gentry-Maharaj, A Hein, AS Whittemore, A Jensen, A Du Bois, A Brooks-Wilson, A Rudolph, A Jakubowska, AH Wu Show all
Fertility and Sterility | ELSEVIER SCIENCE INC | Published : 2016
Abstract
Objective To evaluate whether endometriosis-associated genetic variation affects risk of ovarian cancer. Design Pooled genetic analysis. Setting University hospital. Patient(s) Genetic data from 46,176 participants (15,361 ovarian cancer cases and 30,815 controls) from 41 ovarian cancer studies. Intervention(s) None. Main Outcome Measure(s) Endometriosis-associated genetic variation and ovarian cancer. Result(s) There was significant evidence of an association between endometriosis-related genetic variation and ovarian cancer risk, especially for the high-grade serous and clear cell histotypes. Overall we observed 15 significant burden statistics, which was three times more than expected. Co..
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Awarded by National Institutes of Health
Funding Acknowledgements
This work was supported by the National Cancer Institute (K07-CA095666, K07-CA80668, K07-CA143047, K22-CA138563, N01-CN55424, N01-PC67001, N01-PC067010, N01-PC035137, P01-CA017054, P01-CA087696, P30-CA072720, P30-CA15083, P30-CA008748, P50-CA159981, P50-CA105009, P50-CA136393, R01-CA149429, R01-CA014089, R01-CA016056, R01-CA017054, R01-CA049449, R01-CA050385, R01-CA054419, R01-CA058598, R01-CA058860, R01-CA061107, R01-CA061132, R01-CA063678, R01-CA063682, R01-CA067262, R01-CA071766, R01-CA074850, R01-CA076016, R01-CA080978, R01CA083918, R01-CA087538, R01-CA092044, R01-CA095023, R01-CA122443, R01-CA112523, R01-CA114343, R01-CA126841, R01-CA136924, R03-CA113148, R03-CA115195, U01-CA069417, U01-CA071966, and Intramural research funds); the European Commission's Seventh Framework Programme (agreement number 223175 HEALTH F2 2009-223175); a National Cancer Institute, Cancer Post-GWAS Initiative (U19-CA148112); the Genetic Associations and Mechanisms in Oncology (GAME-ON); the Ovarian Cancer Research Fund (thanks to donations by the family and friends of Kathryn Sladek Smith) (PPD/RPCI.07); the National Institute of Environmental Health Sciences (T32ES013678 to A.W.L.); National Health and Medical Research Council (to G.-C.T.); American Cancer Society Early Detection Professorship (SIOP-06-258-01-COUN to B.K.); National Center for Advancing Translational Sciences (NCATS) (UL1TR000124 to B.K.); California Cancer Research Program (00-01389V-20170, N01-CN25403, 2II0200); the Canadian Institutes of Health Research (MOP-86727); Cancer Australia; Cancer Council Victoria; Cancer Council Queensland; Cancer Council New South Wales; Cancer Council South Australia; Cancer Council Tasmania; Cancer Foundation of Western Australia; the Cancer Institute of New Jersey; Cancer Research UK (C490/A6187, C490/A10119, C490/A10124); the Danish Cancer Society (94-222-52); the ELAN Program of the University of Erlangen-Nuremberg; the Eve Appeal; the Helsinki University Central Hospital Research Fund; Helse Vest; the Norwegian Cancer Society; the Norwegian Research Council; the Ovarian Cancer Research Fund; Nationaal Kankerplan of Belgium; the L & S Milken Foundation; the Polish Ministry of Science and Higher Education (4 PO5C 028 14, 2 PO5A 068 27); the Roswell Park Cancer Institute Alliance Foundation; the National Institutes of Health/National Center for Research Resources/General Clinical Research Center (MO1-RR000056); the US Army Medical Research and Material Command (DAMD17-01-1-0729, DAMD17-02-1-0666, DAMD17-02-1-0669, W81XWH-07-0449, W81XWH-10-1-02802); the U.S. Public Health Service (PSA-042205); the National Health and Medical Research Council of Australia (199600, 400281); the German Federal Ministry of Education and Research of Germany Programme of Clinical Biomedical Research (01 GB 9401); the State of Baden-Wurttemberg through Medical Faculty of the University of Ulm (P.685); the German Cancer Research Center; the Minnesota Ovarian Cancer Alliance; the Mayo Foundation; the Fred C. and Katherine B. Andersen Foundation; the Lon V. Smith Foundation (LVS-39420); the Oak Foundation; the Oregon Health & Science University Foundation; the Mermaid I project; the Rudolf-Bartling Foundation; the UK National Institute for Health Research Biomedical Research Centres at the University of Cambridge, Imperial College London, University College Hospital ''Womens Health Theme'' and the Royal Marsden Hospital; and WorkSafeBC 14.